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TBS iNsightTM - an advanced imaging software for bone densitometers (DXA) - enhances the ability to predict osteoporotic fracture risk. The result - expressed as a Trabecular Bone Score (TBS) - derives from a patented algorithm that evaluates pixel gray-levels and spatial variations in the AP spine DXA scan, providing an indirect, yet highly correlated, index of bone microarchitecture that is mostly independent of bone mineral density (BMD), clinical risk factors and FRAX®. TBS’ maximal impact is observed in patients with osteopenic/ normal BMD values who display low TBS scores and consequently have a higher combined risk profile. Furthermore, when added to FRAX, TBS' greatest utility is seen in patients whose BMD is close to an intervention threshold.